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Firstly, MDPV (also known as NRG-1 and 3,4-Methylenedioxypyrovalerone) is a novel, extremely potent synthetic stimulant substance of the cathinone and pyrrolidine chemical classes that produces states of extreme stimulant euphoria, dis-inhibition, and sexual arousal when administered. MDPV is the 3,4-methylenedioxy ring-substitute analog of the compound a-PVP.
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IUPAC: 1-(1,3-Benzodioxol-5-yl)-2-(pyrrolidin-1-yl)pentan-1-one.MDPV Powder for sale
Methylenedioxypyrovalerone has no record of FDA approved medical use. It has been shown to produce robust reinforcing effects and compulsive self-administration in rats, though this had already been provisionally establishe by a number of documented cases of misuse and addiction in humans before the animal tests were carried out.
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Thirdly, MDPV is the 3,4-methylenedioxy ring-substitute analog of the compound pyrovalerone, develope in the 1960s, which has been use for the treatment of chronic fatigue and as an anorectic, but cause problems of abuse and dependence.
In this paragraph, Other drugs with a similar chemical structure include α-pyrrolidinopropiophenone (α-PPP), 4′-methyl-α-pyrrolidinopropiophenone (M-α-PPP), 3′,4′-methylenedioxy-α-pyrrolidinopropiophenone (MDPPP) and 1-phenyl-2-(1-pyrrolidinyl)-1-pentanone (α-PVP).
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Secondly, MDPV acts as a stimulant and has been report to produce effects similar to those of cocaine, methylphenidate, and amphetamines.
In this paragraph, The primary psychological effects have a duration of roughly 3 to 4 hours, with aftereffects such as tachycardia, hypertension, and mild stimulation lasting from 6 to 8 hours. Moreover, High doses have been observed to cause intense, prolonged panic attacks in stimulant-intolerant users, and there are anecdotal reports of psychosis from sleep withdrawal and addiction at higher doses or more frequent dosing intervals. It has also been repeatedly note to induce irresistible cravings to re-administer.
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In this paragraph, Reported modalities of intake include oral consumption, insufflation, smoking, rectal and intravenous use. It is supposedly active at 3–5 mg, with typical doses ranging between 5–20 mg.
When assayed in mice, repeated exposure to MDPV causes not only an anxiogenic effect but also increased aggressive behaviour, a feature that has already been observe in humans. As with MDMA, MDPV also caused a faster adaptation to repeated social isolation. MDPV Powder for salehttp://Pureresearchchemical.com/
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Finally, A cross-sensitization between MDPV and cocaine has been evidence. Furthermore, both psychostimulants, MDPV and cocaine, restore drug-seeking behavior with respect to each other. Although relapse into drug-taking is always more pronounced with the conditioning drug. Moreover, memories associated with MDPV require more time to be extinguish.