4-MMC Crystal for sale

What is 4-MMC?

4-methylmethcathinone, 4-MMC, and 4-methylephedrone,is a synthetic stimulant drug belonging to the amphetamine and cathinone classes. It is commonly referred to by slang names such as drone,^[5] M-CAT,^[6] white magic,^[7] meow meow, and bubble.^[8] Chemically, it is similar to the cathinone compounds found in the khat plant, native to eastern Africa.

Mephedrone is typically found in tablet or crystal form,^[10] and users may swallow, snort, or inject it. Its effects are similar to those of MDMA, amphetamines, and cocaine, producing euphoria and increased sociability. Mephedrone is rapidly absorbed, with a half-life of about 2 hours, and is primarily metabolized by CYP2D6 enzymes. Its effects are dose-dependent. Side effects can include cardiovascular changes^[4]: 13 and anxiety.

Mephedrone was first synthesised in 1929 but remained relatively obscure until it was rediscovered around 1999–2000. At that time, it was legal to produce and possess in many countries. By 2000, mephedrone was available for sale on the internet. By 2008, law enforcement agencies had become aware of the substance, and by 2010, it had been reported in most European countries, with significant prevalence in the United Kingdom. Mephedrone was first made illegal in Israel in 2008, followed by Sweden later that year. By 2010, many European countries had banned the substance, and in December of that year, the European Union ruled it illegal. In Australia, New Zealand, and the United States, it is considered an analog of other illegal drugs and can be controlled under laws similar to the US Federal Analog Act. In September 2011, the US temporarily classified mephedrone as a Schedule I drug, with the classification taking effect in October 2011. This was made permanent in July 2012 with the passage of the Synthetic Drug Abuse Prevention Act (SDAPA)^.

Mephedrone is rapidly absorbed and eliminated in humans. After oral or intranasal administration, peak plasma concentrations are typically reached within 0.5 to 1 hour.^[11] The drug crosses the blood-brain barrier easily, with a brain-to-plasma ratio of approximately 1.85 in rats.^[11] It has a relatively short half-life of approximately 2 hours in plasma and whole blood.^[78] The drug and its metabolites can be detected in whole blood and plasma for up to 6 hours post-administration, with some metabolites persisting longer.^[11][78]

Mephedrone exhibits enantioselective pharmacokinetics. The R-(+) enantiomer shows higher peak concentrations and a longer half-life compared to the S-(-) enantiomer. The absolute bioavailability of mephedrone is relatively low, at about 10% in rats, suggesting a significant first-pass effect.^[11] The percentage of mephedrone bound to plasma proteins is approximately 22%.^[11]

These pharmacokinetic properties contribute to mephedrone’s rapid onset of action, short duration of effects, and the tendency for users to engage in repeated dosing to maintain the desired effects.