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What is JWH-018 Powder?

JWH-018 also called 1-pentyl-3-(1-naphthoyl)indole or AM-678 is an analgesic chemical that produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products that in some countries sold legally as “incense blends”. JWH-018 Powder for sale

IUPAC: Naphthalen-1-yl-(1-pentylindol-3-yl)methanone
Molecular Formula: C24H23NO
CAS#: 209414-07-3
Appearance: White Powder
Purity: 99%

JWH-018 is a full agonist of both the CB1 and CB2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB1 and 2.94 ± 2.65 nM at CB2.[3] JWH-018 has an EC50 of 102 nM for human CB1 receptors, and 133 nM for human CB2 receptors.  It produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, suggesting potent cannabinoid-like activity.

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Metabolism of JWH-018 was assess using Wistar rats which had been administered an ethanolic extract containing JWH-018. Urine was collect for 24 hours, follow by extraction of JWH-018 metabolites using both liquid-liquid extraction and solid-phase extraction.

GC-MS was utilize to separate and identify the extract compounds. JWH-018 and its N-dealkylated metabolite were only detect in small amounts, with hydroxylated N-dealkylated metabolites comprising the primary signal.

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At least one case of JWH-018 dependence have been capture by the media.[2] The user consumed JWH-018 daily for eight months. Withdrawal symptoms were more severe than those experienced as a result of cannabis dependence. JWH-018 have been see to cause profound changes in CB1 receptor density following administration, causing desensitization to its effects more rapidly than related cannabinoids.

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Compared to THC, which is a partial agonist at CB1 receptors, JWH-018, and many synthetic cannabinoids, are full agonists. THC has been see to inhibit GABA receptor neurotransmission in the brain via several pathways. JWH-018 may cause intense anxiety, agitation, and, in rare cases (generally with non-regular JWH users), has been assumed to have been the cause of seizures and convulsions by inhibiting GABA neurotransmission more effectively than THC.