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Metonitazene Powder for sale
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Metonitazene Powder for sale
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Metonitazene Powder for sale

Rated 5.00 out of 5 based on 1 customer rating
(1 customer review)

$1,250.00 – $18,000.00

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Description

Buy Metonitazene Powder

What is Metonitazene ?

Firstly, Metonitazene is an analgesic compound related to etonitazene, which was first reported in 1957,and has been shown to have approximately 100 times the potency of morphine by central routes of administration, but if used orally it has been shown to have approximately 10 times the potency of morphine. Metonitazene Powder for sale

Secondly, Its effects are similar to other opioids such as fentanyl and heroin, including analgesia, euphoria, and sleepiness. Adverse effects include vomiting, and respiratory depression that can potentially be fatal.[8] Because of high dependency potential and dangerous adverse effects it has never been introduced into pharmacotherapy. Metonitazene Powder for sale

Thirdly, Metonitazene, has been described as a white or off-white/beige powder, sometimes referred to as crystalline in consistency (Cayman Chemicals, 2020; Krotulski et al., 2021; PubChem, 2020). The free base and the hydrochloride salt appear as a white or colored powder. Moreover, the citrate salt is describe as a crystalline solid (Cayman, 2021a).

Chemical Properties
Melting point
The melting point of metonitazene is 76–78 °C as free base and 197–198 °C as hydrochloride salt (Ujváry et al., 2021, Hunger et al., 1960a).

Where to buy Metonitazene Powder?

Unedited- Advance copy
44th ECDD (2021): Metonitazene
Page 8 of 38
most importantly,There is no information on the actual method and scale of manufacture of 2-benzylbenzimidazoles that have recently been detect although several methods are simple and cost-efficient, not requiring regulated precursors (Ujváry et al., 2021).E. Chemical Properties
Melting point
Moreover, the melting point of metonitazene is 76–78 °C as free base and 197–198 °C as hydrochloride salt (Ujváry et al., 2021, Hunger et al., 1960a).

Solubility

Moreover, Metonitazene is lipophilic, as are its homologues etonitazene and isonitazene. Moreover, the calculated octanol/water distribution coefficient for metonitazene is logP=3.734±0.936 at
25 °C (Cayman, 2021b). Metonitazene free base has a solubility in dimethylformamide (DMF) of 25 mg/mL
and of 20 mg/mL in dimethyl sulfoxide (DMSO).

Finally, In a mixture of DMF and phosphate- buffered saline (PBS) DMF:PBS (pH 7.2) (1:1), the free base is soluble at 0.5 mg/mL and at
10 mg/mL in ethanol (Cayman, 2021b). Metonitazene citrate is soluble in DMF and DMSO at 10 mg/mL and at 1 mg/mL in PBS (pH 7.2) (Cayman, 2021a). Order AThttps://www.pureresearchchemical.com/product/metonitazene-powder-for-sale/

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Quantity

10 Grams, 50 Grams, 100 Grams, 250 Grams, 500 Grams, 1Kilogram

Reviews (1)

1 review for Metonitazene Powder for sale

  1. Rated 5 out of 5

    Richard Machado – December 15, 2022

    Best product in my opinion. And the costumer services is great. Keep up the good work

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PHP is commonly referred to as alpha-pyrrolidinyl-hexaphenone, PHP, and alpha-PHP. The IUPAC name for a-PHP is (±)-1-Phenyl-2-(1-pyrrolidinyl)-1-hexanone. We can look at the research conducted on this research chemical.
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The family of phenylpiperidines (characterized by a phenyl moiety directly linked to a piperidine) includes also the NSO fentanyl (synthesized by P. Janssen in the 1960s) and its analogs, up to 1000 times more potent as analgesic than meperidine and differing in structure from the latter for a phenethyl group on the piperidine nitrogen in place of a methyl group (Elbaridi et al., 2017; Raffa et al., 2018).While extensive literature has been published in regards to pharmacology and toxicology of fentanyl and its illicit analogs (Bäckberg et al., 2015; Mounteney et al., 2015; Dwyer et al., 2017; Giorgetti et al., 2017; Guerrieri et al., 2017; Helander et al., 2017a; Pichini et al., 2017a,b; Shoff et al., 2017; Suzuki and El-Haddad, 2017), the pharmacological and toxicological properties of non-fentanyl derived NSOs have not yet been reviewed in detail.Compounds such as U-47700, U-51754, U-49900, U-448800, AH-7921 from the chemical family of benzamide, U-50488 and U-51754 from the acetamide family and MT-45 from the piperazine family are the NSOs most recently reported as health threats for opioids consumers (Mohr et al., 2016; Amin et al., 2017; Baumann et al., 2017; Domanski et al., 2017; Fabregat-Safont et al., 2017; Prekupec et al., 2017; Marchei et al., 2018). Indeed, this new generation of derivatives has been involved in a number of recent overdose deaths worldwide (Drug Enforcement Administration [DEA], 2016; Baumann et al., 2017; Domanski et al., 2017; Fabregat-Safont et al., 2017).Clandestine manufacturing of NSOs has been pirated from scientific literature or patent filings published by pharmaceutical companies attempting to search for new therapeutic drugs without addiction-related adverse effects (Logan et al., 2017).In a similar manner to fentanyl derivatives, these NSOs are being partly used as heroin adulterants or as constituents of counterfeit pain pills and they can be bought directly by users from online vendors via conventional web or cryptomarket (European Monitoring Centre for Drugs, and Drug Addiction [EMCDDA], 2016; Armenian et al., 2017b; Baumann et al., 2017; Van Hout and Hearne, 2017).Similarly to morphine and heroin (opiates) or to semi-synthetic opioids (like hydro- and oxycodone, hydro- and oxymorphone), these compounds produce CNS depressants effects such as respiratory depression, analgesia, hypothermia, sedation, euphoria, anxiety, sweating, disorientation, drowsiness, nausea, and miosis (Carroll et al., 2012; Guerrini et al., 2013; Hill and Thomas, 2016; Armenian et al., 2017b), and although the effects of tolerance and dependence may rapidly reach high levels, elevated risks of overdose and death are frequent for these compounds (United Nations Office on Drugs and Crime [UNODC], 2017b). Furthermore, the typical rewarding characteristics and the easy availability induce users to abuse of these opioids (Carroll et al., 2012).The main NSOs AH-7921, MT-45, and U-47700 have been identified in Europe between 2013 and 2016, and over 40 deaths were reported to the European Monitoring Centre for Drugs and Drug Addiction in a short time after that AH-7921 and MT-45 were found out on the European drug market (EMCDDA) (European Monitoring Centre for Drugs, and Drug Addiction [EMCDDA], 2017). Moreover, in 2016 U-47700 has been the cause of at least 46 confirmed fatalities as well as the subject of 88 reports from forensic laboratories submissions in the United States (Fabregat-Safont et al., 2017).Since the popularity of these substances is rapidly increasing and evolving over time, there is a great need to update all possible information, particularly with respect to their subjective and side effects and to tackle unsolved issues, including limited analytical methods to disclose and monitor different compounds (Katselou et al., 2015; Lucyk and Nelson, 2017).To fill this gap, we here sought to report the latest information available on non-fentanyl derived NSOs U-47700, U-50488, U-51754, U-49900, U-48800, AH-7921, and MT-45 with particular regard to their pharmacotoxicology and adverse effects on users (see Figure 1).We report a method for the detection and quantitation of 12 drugs and 2 metabolites in the same structural class as the illicit mu-opioid agonist U-47700 in human whole blood. These substances are either known or suspected to be present as potential novel opioids in illicit drug markets. The general class of these drugs was developed in pharmaceutical research programs in the 1970s, but these drugs have recently become of concern for overdoses and death in opioid users in the USA and internationally. The scope of analysis included the following compounds: methylenedioxy U-47700, ethylenedioxy U-47700, ethylenedioxy U-51754, U-69593, U-47931E (bromadoline), U-47700, U-48800, U-49900, U-51754, U-50488, propyl U-47700 and isopropyl U-47700. Additionally, two metabolites N,N-didesmethyl U-47700 and desmethyl U-47700 were also included in the scope. Drugs were extracted from human whole blood using solid-phase extraction, and the extracts were analyzed by liquid chromatography--tandem mass spectrometry. The assay was validated with respect to bias, carryover, interference, within-run and between-run precision, and accuracy. Eight medicolegal death investigation cases that had screened positive for U-48800 by liquid chromatography--time-of-flight mass spectrometry were successfully confirmed and quantified using this method. The mean and median concentrations of U-48800 in these cases were 2.5 (±2.1) and 1.8 ng/mL, respectively, with a range of concentrations of 0.27–6.2 ng/mL. Case history information including the presence of other drugs in combination are described and discussed.
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