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SGT-78 (also known as CUMYL-CYBINACA or CUMYL-4CN-BINACA) is an indazole-3-carboxamide based synthetic cannabinoid that has been sold online as a designer drug. While the in vitro activity of this compound is not disclosed in the associated patent, anecdotal reports suggest it is a potent cannabinoid agonist with an active dose of around 0.1mg.SGT-78 Powder for sale
SGT-78 for sale online and all other synthetic cannabinoids purchase on this website are intend for research and forensic applications. The research chemical called SGT-78 is a designer drug with pronounced physiological and psychoactive effects and has the molecular formula C22H24N4O. The formula weight has the value 360.5 g/mol.
Synthetic cannabinoids like SGT-78 might display high affinity for peripheral CB1 and CB2 cannabinoid receptors. (4-cyanobutyl)-N-(1-methyl-1-phenylethyl)-1H-indazole-3-carboxamide and all other designer drugs purchase on this website are intend for research and forensic applications.
CUMYL-4CN-BINACA (also known as CUMYL-CYBINACA or SGT-78) is an indazole-3-carboxamide base synthetic cannabinoid that has been purchase online as a designer drug.[1][2][3][4][5][6] It is a potent agonist for cannabinoid receptors CB1 and CB2, with in vitro EC50 values of 0.58 nM and 6.12 nM, respectively.
CUMYL-4CN-BINACA is metabolize to produce cyanide, raising concerns about liver toxicity. There is one report case of hyperthermia, rhabdomyolysis, and kidney failure associated with its use.
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Medical uses include the treatment of nausea due to chemotherapy, spasticity, and possibly neuropathic pain.[7] Common side effects include dizziness, sedation, confusion, dissociation, and “feeling high”.[7]
Before the 1980s, cannabinoids were speculat to produce their physiological and behavioral effects via nonspecific interaction with cell membranes. Instead of interacting with specific membrane-bound receptors. The discovery of the first cannabinoid receptors in the 1980s helped to resolve this debate.[8] These receptors are common in animals. Two known cannabinoid receptors are termed CB1 and CB2,[9] with mounting evidence of more.[10] The human brain has more cannabinoid receptors than any other G protein-coupled receptor (GPCR) type.SGT-78 Powder for salehttps://www.pureresearchchemical.com/product/sgt-78-powder-for-sale
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